What are you suggesting? do you see this "99%" as ruling out things that would not be useful in human medicine? To be frank it appears from my perspective that you are saying things about the murine model in comparison with humans, without any actual evidence to back up your assertions. Opinions offered without evidence may be dismissed without evidence, or so the saying goes. Do you want to elaborate? I'm pretty sure everyone would agree that mice and humans are not the same species.

In support of the Murine Model, I will offer this: The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research https://pmc.ncbi.nlm.nih.gov/articles/PMC3987984/

"Based on a report from the Tufts Center in 2001, it is estimated that of 5,000–10,000 compounds that enter the development pipeline, 250 will make it to preclinical trials and of those, only five will move into human clinical trials. Of those five, on average, only one will actually make it to market. "

Your numbers are off, according to this, it's more like 1/5,000-10,000 or 0.0002 to 0.0001. Regardless I'm curious what you are suggesting? Organoids? Yep, they are being used and it's likely they will continue to improve.

If you don't wish to elaborate, that's ok with me. I'll just assume your assertions are baseless, and move on. Have a great day!