Kind of like how in physics people tend to say "why doesn't anyone make truly big discoveries anymore?" It's because the easy targets for modeling and connecting have all been looked at for the most part. There aren't as many "unexplained effects" in our every day world that people can readily study with every-day means. The edge of discovery has been pushed to the world of high-tech instrumentation and simulation.

With medicine, the easy-to-cure stuff has all been tackled, we made anti-biotics that cured a massive amount of normal, killer diseases that plagued us for a million years. We made vaccines for viruses that don't constantly spread and evolve like polio and measles and so on. The ones we're having the hardest time with are the very complicated ones.

[–] chaogomu@lemmy.world 5 points 1 day ago

There's a pill that just finished phase 1 trials that can cure osteoarthritis.

Well, it's a treatment that allows joint cartilage to regrow and heal properly.

It also reverses age related muscle loss.

Now, these things can come back, but they need to degrade naturally again. Probably. We don't know how fast the degradation will set in once the suppression of the gerozyme is removed.

If you want to learn more, look up 15-PGDH inhibitors. I'd link to the Stanford study, but that's a bit hard from my phone.

As someone who has arthritic knees, I've been following the various clinical trials closely.