this post was submitted on 27 Dec 2025
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Murdered by Words

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[–] minnow@lemmy.world 64 points 4 months ago (22 children)

Here's the thing: there's a real answer to that question.

What makes a trans woman a woman is her brain has developed as a woman's brain. This development is set in progress while still in utero, and can become apparent as the relevant parts of the brain develop later. This is why many tabs people report realizing they were the opposite gender between the ages of 3 and 8.

Here are a number of studies that show the biological reality of transgender people. It’s important to note that although some of these studies suggest causation (ie, HOW a person is born transgender) we can’t know if there’s more than one cause, and therefore using any one test to see if somebody is “biologically trans” is impossible.

Sex vs Gender and the role of the SRY gene specifically (as opposed to the Y chromosome generally) in the development of each, as well as the possible role of AR (androgen receptor) gene https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505576/

A correlation is found between AR allele repeat length and a person being transgender https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402034/

The brains of trans people more closely resemble those of their chosen gender identity than their natal sex https://www.ese-hormones.org/media/1506/transgender-brains-are-more-like-their-desired-gender-from-an-early-age.pdf

A trans person's brain more closely resembles their chosen gender as demonstrated by their brain's response to olfactory stimulation with androstadienone https://www.frontiersin.org/articles/10.3389/fendo.2014.00060/full

Estrogen signaling pathways identified which tell the brain to develop as one gender or the other, as well as mechanisms by which physical development can happen in one way while brain development can happen in the other https://www.nature.com/articles/s41598-019-53500-y

Cornell University summarizes 72 studies regarding the effect of gender transition on transgender well-being (with links to all 72 studies) https://whatweknow.inequality.cornell.edu/topics/lgbt-equality/what-does-the-scholarly-research-say-about-the-well-being-of-transgender-people/

[–] Flax_vert@feddit.uk 3 points 4 months ago (2 children)

Don't people refer to this as "transmedicalism" or "truscum"? In addition, why do many transgender people act more similarly to their agab? (Eg, some trans women act like men, some trans men act like women)

[–] minnow@lemmy.world 10 points 4 months ago (1 children)

No, transmedicalism is the belief that somebody isn't actually trans unless they meet certain medical criteria. I'm saying the opposite: that the lack of any particular medical criteria can't be used to invalidate somebody being trans.

As for your second question, how a person behaves is a matter of nurture more than nature, but it's also deeply engrained from a very early age. Even those trans people who put the effort in to overcoming this socialization can have old habits they struggle to get rid of.

[–] Flax_vert@feddit.uk 3 points 4 months ago

That's interesting

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