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As far as I've seen, use comes with a very slightly increased chance of kidney failure, pancreatitis and a rare form of thyroid cancer. These are known and well studied drugs that are being used to treat different conditions than they previously were, so there's not some huge lack of information as was implied. Idk what they're referring to specifically, but that's everything I've been able to find from looking into them recently.

Just gonna say this, there is a massive amount of work that goes into creation, validation, and maintenance of information for these drugs even after they’re out on the market. These may have become a hot drug category as soon as it caught on that it was good for treating obesity as well as diabetes, but that doesn’t mean that they aren’t continually doing work in the background to keep information, including incidences and likelihood of side effects, up to date.

https://www.aoa.org/news/clinical-eye-care/public-health/glp-1-receptor-agonists-and-vision-risk

GLP1s have been making people go blind. If you don't have diabetes, taking these drugs seem to give you diabetes related symptoms in the long term. Just diet and exercise. Most cheat codes in life come with consequences