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Mewgenics Devlog: Isaac vs Mewgenics
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Ohh man, you have a treasure trove of content ahead of you if you like. He played isaac daily for almost a decade, starting on the flash version.
There are literally thousands of episodes of astute, off the cuff commentary about whatever while he did runs. Markiplier even credited a guide he wrote about streaming to be a big part of why he got started.
Dude doesn't play isaac anymore, but if you enjoy daily, mundane bullshit discussed in an entertaining way, you'll likely enjoy his work.
Oh wow what an OG, I admire his dedication. I have seen so much Isaac runs that I have been desensitized from it a bit, but thank you for your recommendation, lemming.