The meme is from an episode of It's Always Sunny in Philadelphia, and Charlie here has taken a job with another character, Mac, where they are delivering mail in an office complex. Charlie is in the mail room all day while Mac chats up the office staff and pretends to work in someones office while they are on vacation. Charlie gets increasingly paranoid and cooks up this idea that none of the people he's getting mail for actually exist. Mac informs him that not only do these people exist, but they are all wondering where their mail is.

So, no, in the show the crazy one, Charlie, is definitely not right, and almost never is.

Carol? Caaaarol?!