All the comments assume everybody else isn't also immortal. I forget the title and author but there's an old sci fi story (or novel?) about a future where everybody lives for centuries, and they've found that the brain only retains a certain amount of experience. They have long careers, get tired of doing whatever, re-educate and do something else, or even have multiple families they eventually forget about. A couple of the characters are surprised to find out they used to be married like a century earlier. To me that seems vaguely like reincarnation, and I kind of don't hate the idea. I really don't see any downside to that scenario, or even just going on forever.

People are focused on having regrets and negatives that last forever. But buck up li'l camper, you can learn to move on from stuff. And I say this as a dad whose daughter had cancer at age 10 (she survived). It was hell and I wouldn't want to live through that whole period again, but I don't consider it a reason not to want to live forever. The trick is to learn how to cope with these things and not let them outweigh the good experiences you have.