I use ayahuasca in the context of the Santo Daime. Part of the Santo Daime aesthetic is to behave as if you are sober. That's what I mean by adapt.
"The effects potentiate each other, so you will be tripping much harder." -- This is not how I experienced it. To me, the effects of each substance are pretty orthogonal. The combination is not multiplicative or even additive. It's more like being on two separate substances that affect different aspects of experience. However, the cannabis made me less able to adapt as the force of the ayahuasca got stronger.
Now that I've experimented with the combo, I would say that cannabis interferes with the profound impartiality of ayahuasca. I enjoy ayahuasca more without cannabis.
I agree. I found Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey that mentions, "cannabis smoked together with ayahuasca during ceremonies of the Brazilian Santo Daime Church." So I guess the combo is metabolically fine.
Thanks for your concern with my psychological state, but I'm just asking if there is metabolic a counter-indication like for mixing alcohol and opioids. Or the combo of warfarin and ibuprofen.
Church of the Sacred Synthesis March 7 Press Release
The Church of the Sacred Synthesis (The Church) is pleased to announce that it has confirmed the presence of Psilomethoxin (4-HO-5-MeO-DMT) in its mushroom fruiting bodies.
These findings have been independently confirmed using triple quadrupole LC/MS instrumentation at the Chemical Purification, Analysis, and Screening Facility supervised by its director at the University of South Florida (USF) on Tuesday March 5, 2024.
The Church made the Psilomethoxin reference standard that it promised and will be able to test submitted sacramental Psilomethoxin contained in fruiting bodies provided by others who grow the sacrament on their own.
The Church has a distribution partner who will be making Psilomethoxin available over the counter (OTC) in a GMP formulation. We have a biotech partner who will be making Psilomethoxin OTC in a GMP formulation from yeast using gene editing. We have a university partner who will be conducting clinical trials on Psilomethoxin on the way towards an FDA indication.
The Church has sued Usona and others for defamation in Texas state court in Austin. The basis for our suit is that Usona is liable for their test of the anonymous unauthenticated sacrament due to the reckless disregard for the truth (actual malice) in the failure of their methodology to extract Psilomethoxin using methanol rather than water which Psilomethoxin is soluble in.
After some self-experimentation, I'd say that CBN-O is 2-3x stronger than CBN. I'm not sure how long it lasts after ingestion (4-6 hours?), but its effects are mostly gone when I wake up. It's great stuff to aid sleep.