I use a Helix (the big full floorboard one), but I also have a small collection of pedals. I would say its just a big guitar pedal at the end of the day. I will say that stacking lots of effects and amps internally can limit what you run, the DSP is about 6 years out of date - but still powerful if you're careful.
I'd say keep a couple of good drives (which you are), but also keep a flanger as the models in there are not my fave. If you love ambient verbs (eg Strymon/Eventide) then keep one of those. The Helix verbs are good, though, just DSP intensive.