There are a bunch of jokes in this game that I absolutely am not okay with.
Yeah, the whole point of the game is the main character being a horrible asshole.
But then, the game for example makes jokes about a black woman ending up a slave. She ends up as a slave not because the main character is being thoughtless. Yes, his actions affect the result, but it's a pure coincidence he could not have reasonably predicted. The joke boils down to "look, we dare to be this inappropriate."
Some of similar jokes could maybe read as commentary on horrible bigots who really do behave towards other people in the way the protagonist of this game does, because technically the bad things happen to those people because of the protagonist's behaviour. But when the same things sometimes happen to them kind of "just like that", it puts the rest of the jokes in a very different context: The developers of the game actually are making fun of the fact that black people were used as slaves or that women often experience sexual violence.
And then there's also the transsexual who turns out to be the worst stereotype of a transsexual that a MAGA person ever could imagine. And, and, and.
Some of the jokes are kind of more neutral: At one point the protagonist needs to feed some ten-ish children to a monster, camouflaging them as hot dogs and covering them in ketchup and mustard. And then the children do indeed get eaten and the game progresses. I mean, okay, it's super inappropriate in a way, but it's not perpetuating hate speech. But a surprisingly large share of the jokes are punching at various minorities.
I've never seen as much bigotry in a game as I saw in the Deponia trilogy when I played through it.
