Some things that will make this phrecia league different than last phrecia league is that the last one was combined with Settlers league, which had Settlers weapon enchants.
This phrecia league will be combined with Keepers league. Keepers league has foulborn uniques and grafts. Most importantly, bloodline ascendancies have been added to the core game. This will allow you to do a hybrid ascendancy of a Phrecia ascendancy and Bloodline ascendancy.
Settlers nodes have been added to the atlas mod pool after the last phrecia league. Settlers atlas mods on idols could be very powerful. The "lost in transit" node says Settlers ore deposits has a 6% chance to get converted to "lost shipments". I'm predicting that there will be an idol for this mod which offers maybe 10% chance for lost shipment conversion with a possibility for 4 idols of this type. 40% chance of lost shipment conversion would be a very interesting mapping strategy.
There's a settlers node which says that bismuth deposits have a 30% chance to give an additional loot modifier to magic monsters. If this mod is on idols, it could be useful for adding extra loot to monsters. i'm not sure if such a idol mod would allow for multiple loot mods to magic monsters.
The crimson iron node says 2 additional corrupted growths per ore deposit, this could potentially stack to spawn a lot of monsters if on idols. The orichalum ore node says 100% increased duration monster spawning time; this could potentially spawn a lot of monsters.
There could be a keystone idol for "Refiner's Bargain". Refiner's Bargain keystone says that Harvest crops are converted to settler's crops at a 1.5x multipier and delve sulphite is converted to settler's ore at a 0.15x multiplier. In the last settler's league it was possible to reach over 100k Harvest crop juice per map, converting this to settler's crops could be a reasonable way to acquire mirror shards. Converting sulphite to settler's ore could be a reasonable way to acquire tattoos.
My favorite strategy from last phrecia league was divination card strongboxes. It was possible to stack converting strongboxes to divination card boxes and you would get up 3000-4000 divination cards every map.