Nubbys number factory, Soulcalibur, Peak and REPO.
I currently have my left thumb in a splint from surgery so have struggled to play a lot of games. Thankfully with peak and repo, I'm willing to go through the awkwardness to play them with friends and they can help me if I'm finding it too much for something specific. (More so with repo since with peak, i would just instead die, but that's fine).
I'm usually a controller gamer so I've had to readjust back to keyboard and mouse but without the use of a space bar. Sometimes when i can be arsed I get a disability HID set of pedals to use as space, ctrl and shift but sometimes i can get away with binding space to a mouse button.
Last few weeks I played through absolum using my new fight stick which has been a godsend for paying games with my temporary disability. I can cup the stick's ball like a wine glass and never have to use my thumb. So for some games I've even rebinded them fully with the stick. I even played peak a few times with arcade stick for the left hand, mouse with the right hand and pedals for jumping. Its been easier with the previous method i mentioned but that also required me to work up to since for a while my thumb was in the way of my index finger to use a keyboard with.
Sorry for the wall of text. Hopefully someone will find my rambles interesting.