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CRISPR gene-editing works to reduce high cholesterol in a new study (www.npr.org)

submitted 1 week ago by MicroWave@lemmy.world to c/health@lemmy.world

8 comments fedilink hide all child comments

A single infusion of an experimental gene-editing drug appears safe and effective for cutting cholesterol, possibly for life, according to a small early study released Saturday.

The study, which involved 15 volunteers, found one infusion of a drug that uses the CRISPR gene-editing technique could safely reduce cholesterol, as well as levels of harmful triglycerides, by about half.

"Rather than a lifetime worth of medicine, we have the potential to give people a cure," said Dr. Luke Laffin, a preventative cardiologist at the Cleveland Clinic who helped conduct the study. "It's very exciting."

The results of the study were presented Saturday at the American Heart Association's annual meeting and published in The New England Journal of Medicine.

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[–] circledot@feddit.org 2 points 6 days ago (1 children)

How doesn't get that more upvotes?

[–] jet@hackertalks.com 1 points 6 days ago

I did not upvote this, because cholesterol is not a disease. Reducing LDL by itself is not necessarily healthy, especially in the context of a metabolically healthy individual. Chasing intermediate metrics is not something I think is prudent

[–] Tollana1234567@lemmy.today 1 points 6 days ago (2 children)

or you can avoid cholesterol enriched foods. barring someone with inherited high cholesterol which wouldnt be common.

[–] jet@hackertalks.com 1 points 6 days ago (1 children)

Funny story, eating cholesterol does not raise serum cholesterol. If you want to reduce cholesterol, especially triglycerides, the best thing to do is reduce sugar and carbohydrate consumption.

[–] Tollana1234567@lemmy.today 2 points 5 days ago (1 children)

thats why fiber, and vegatables are important they slow down carb absorption.

[–] jet@hackertalks.com 1 points 5 days ago

Sure, but you can also just not eat the carbs to begin with

[–] circledot@feddit.org 1 points 6 days ago

Your body produces cholesterol. That's why editing the corresponding genes work.

[–] jet@hackertalks.com -1 points 6 days ago

I look forward to the all cause mortality data on these edited people