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Major cause of inflammatory bowel disease found
(www.bbc.com)
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this post was submitted on 05 Jun 2024
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The "weak spot" is an enhancer region about 290 Kbp from the gene ETS2 mentioned elsewhere in the comments. The haplotype associated with IBS leads to overepression of the gene. They did some nice cell and molecular work to confirm the enhancer's effect on the gene and the genes effect on inflammation response.