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I definitely think that some of my hesitations have to do with not having any experience of using chemicals that affect the mood before, so I don't have a mental model that I can re-use for antidepressants. I definitely drink caffeine though, so it's probably valid to say that I have constructed a fiction of me never having done anything like this, but it's a convincing fiction.
I think of it like a sci for scenario where Earth is destroyed. There’s a new planet and some people might be thinking “but it’s not the same”, but I say it’s better than death.
Without the antidepressants, my emotional world was a charred landscape of pain and misery. No place for a life, even if it is more “natural”.
There’s nothing natural about a helicopter airlifting you out of the water, but the loss of natural is made up for by no longer drowning in a roiling sea.
Just try it for a month. If you decide there’s something too valuable missing with the loss of your “natural” state of mind, you can go back.