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There are quite a few of these
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Cleopatra VII would be one of these; she's always depicted as being beautiful, but she was so inbred that she put Charles II of Spain to shame. Just look at this family ~~tree~~wreath:
Cleopatra's coefficient of inbreeding was a fucking staggering 0.45, so almost half her alleles were probably identical. Charles II's inbreeding coefficient was a paltry 0.25 and he looked like this, so I leave it to you to ponder how hot Cleopatra would have been exactly:
Yeah, that inbreeding coefficient just proves harder in my mind that Cleopatra looked Greek as fuck, and maybe looked a little.... melted