Police no, but municipalities yes IMO. If Montreal / Winnipeg choose to turn a blind eye to victimless crimes, they should be able to do so and order their police to ignore offenses. Much like how here in SK the provincial government passed laws requiring provincial oversight and handling of any federal firearms appropriation, making it so the feds couldn't simply demand we turn over our guns after Trudeau's gun grab.

If the federal government wants to enforce their drug laws they can send the RCMP to enforce them, like the DEA does in the USA. It shouldn't fall on local police departments to enforce unpopular federal laws.