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Depends what you use, we used to use Sai2 and while it runs in Linux perfectly fine with Wine or WinBoat, its file system is so complicated getting around it’s not worth the hassle. And our cracked Premiere Pro didn’t work on Linux either for obvious Adobe don’t work on Linux reasons, but honestly we switched to Krita for drawing and Kdenlive for video editing and both alternatives were if not the same, better than what we were using before. So realistically it’s just looking at what you use daily, searching if it’s Linux native, if not works with proton/wine/winboat and if all else find an alternative- there’s so many resources it’s pretty easy ti switch now esp if your a gamer (minus any typical kernel anti cheat BS they pull, shouldn’t play those games anywho) if you’d like feel free to reply software you use a lot and we can suggest alts from what we know.

Ps. Don't stress about the distro, there’s no wrong answer (as long as it’s not unbuntu lmao)