this post was submitted on 18 Mar 2026
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Science

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Scientists inject one tumor and watch cancer vanish across the body (www.sciencedaily.com)
submitted 1 day ago by remington@beehaw.org to c/science@beehaw.org
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Summary:

A redesigned cancer immunotherapy is showing striking early results after decades of disappointment with similar drugs. Researchers engineered a more powerful CD40 agonist antibody and changed how it’s delivered—injecting it directly into tumors instead of into the bloodstream. In a small clinical trial of 12 patients with metastatic cancers, six saw their tumors shrink and two experienced complete remission.

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[–] Powderhorn@beehaw.org 16 points 1 day ago (1 children)

... in two out of 12 people. This is certainly a promising breakthrough, and a 17% chance of complete remission is a hell of a lot better than zero. It will be interesting to see the results of the Phase 2 trial.

[–] Hirom@beehaw.org 1 points 14 hours ago* (last edited 14 hours ago) (1 children)

For approval, a new treatment has to show it's better than already approved treatments. Not better than nothing.

This appear to target difficult to treat cancer so any result is encouraging, especially in a clinical trial.

[–] Powderhorn@beehaw.org 4 points 14 hours ago

Sure, but chemo has such absurd side effects that coming up with a new approach is going to be great even if it's maybe less effective.