The side effects they're finding are that it unexpectedly prevents Alzheimer's symptoms and other neurodegenerative issues, influences the brain to want to drink less alcohol and smoke/vape/chew less nicotine, and helps with chronic pain.

The point, though, is that it makes metabolic changes by having people eat less. Pointing out problems with drugs that increase resting metabolic rate (so that they burn more calories without exercising) or decrease absorption of macronutrients in digestion (so that they take in fewer calories from the same food) doesn't really inform how we look at these behavior-altering and desire-altering drugs. They're losing weight by eating less, not by interrupting the relationship between eating and net caloric intake.