In August an immunologist declared the "Leonardi Effect" had received a "decent burial"
Fast forward to today: a new preprint shows what I warned about in 2020
Persistent SARS-CoV-2-induced impairment of CD8 T cell responses to community-acquired pathogens
I was right
Key finding: Post-COVID patients show markedly reduced T cell reactivity to common pathogens (influenza, Staph, VCZ) which is evidence of lasting immune dysregulation favoring secondary infections and viral reactivation
This is the scenario I described years ago: accelerated CD8 aging/paralysis/exhaustion/senescence, poorer control of pathogens.
We ignored it at our peril. Rising "mystery" infections, cancers, herpes flares? Not a coincidence
after covid, patients show profound mitochondrial defects in T cells specific for common pathogens
Classic signs of T cell exhaustion/senescence
This is the scar I predicted in 2020
Aged, dysfunctional T cells that can’t properly control chronic viruses
Science eventually catches up.
Protect your T cells: vaccinate, mask in crowds, avoid reinfection
I read this Wired article about the current flu season and they still inject the “covid immunity debt” as if it was still relevant or even real.
We'll be doing this ten years from now and people will blame the brief moment in time where we took action to not spread as much disease.