this post was submitted on 04 Jan 2026
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Anti-Aging Injection Regrows Knee Cartilage and Prevents Arthritis (scitechdaily.com)
submitted 4 months ago by Lemmar@lemmy.today to c/science@lemmy.world
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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[–] angrystego@lemmy.world 4 points 4 months ago

Well, that's part of what you'd have to consider. The reply didn't state it would be contraindicated in reproductive age, just that it shouldn't be applied without consideration.