this post was submitted on 04 Jan 2026
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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[–] 87Six@lemmy.zip 13 points 6 days ago (1 children)

TONIGHT ON DEAL OR NO DEAL:

you can get this new leg but it will cost you a kidney

[–] MrShankles@reddthat.com 6 points 6 days ago (2 children)

I only need one kidney, AND I can have 3 legs. Deal

[–] Hazy@aussie.zone 2 points 5 days ago

I already have 3 😏

[–] Sciaphobia@sh.itjust.works 1 points 5 days ago

But you have to rename yourself Toejam and befriend someone named Earl.