I'm not a huge fan of the isekai genre, but that doesn't mean I hate it either; its ubiquity is what makes me wonder why people don't just make straight up fantasy anime.
Frieren for example would be terrible if Frieren was actually some random person from earth who got sent into her setting (or, as Frieren's whole thing is outliving her comrades, her purple haired protege was the isekai'd protagonist); I understand how the isekai nature of an anime can also affect the anime, for example a character who has modern world knowledge he applies in the setting, or modern world tech, but if he just becomes a part of it, and NOTHING from his real life has any impact on the setting....then what's the point?
Overlord for example (which I didn't enjoy to be honest; I googled if he ever faces a challenge and nope, entire series and he has zero things that can challenge him) would not have been affected if he was just some lich who woke up a thousand/hundred years later.
Konosuba benefits from the isekai genre in that the isekai elements keep being relevant throughout (Spoilers:
spoiler
for example that guy who chose to reincarnate into the world with a powerful sword that Kazuma stole, or Kazuma dying and Aqua's replacement reviving him repeatedly, or that the demon lords at some point realized all their most annoying hero enemies keep starting in this one town and so decide to attack it, or that ancient scientist who turns out to be have been an isekai'd hero who creates stuff inspired by stuff he was a fan of
Most isekai animes today just seem to be wish fulfillment harem animes, which are a problem on their own as well, but they're paired with being isekais too (if you're wondering why I didn't make a thread on wish fulfillment harem animes, it's cause by and large I avoid them like the plague).
There are some interesting POST isekai stories that I found fascinating, stories where the characters came back from the isekai world and had their powers with them; in one case some of the heroes become devastatingly powerful villains who destroy entire cities, in another case it's a comedy about some guy who comes back and....could have been funnier without the ecchi/SA nonsense happening throughout.
Animes like SAO (which I didn't find interesting beyond the first story) make the other world an entirely false world and never let you forget the characters are real people who can actually die in the real world (sort of an anti-isekai genre).
In general, if they're not going to benefit from being isekai....then just make them normal fantasy. So many good fantasy animes out there that would have been hurt by making the protagonist just an isekai'd character.
i don't remember watching much anime that actually acknowledges the isekai as anything more than the reason the main character is overpowered (either by previous life knowledge or by a gift of some entity at the moment of the transition). they could be the standard fantasy setting with a god giving them some blessing and stories would work exactly the same, since the point of them is usually the power fantasy. it's just currentls the best selling setting for light novels (where most of the isekai stories come from) so writers and publishers are pushed to create more stories where most of the time the isekai topic is completely ignored. before this, the magic school was the standard setting and there were many animes like that
there are many "transported to other world" (pre isekai as a common genre) stories that are interesting to watch where the setting actually drives the story and having the caracter knowing nothing of the world is the interesting part. i cannot remember a single one that is recent so they are usually older works that have different problems (the most comon one is the "chosen one" trope).
I REMEMBER! It was a self imposed rule of mine that if a plot summary said anything about academies, schools, student, etc I wouldn't touch it! More than half the animes on lists I'd see had that in their summaries!
The Faraway Paladin is what Id call a Good isekai (at least I like it, there's a lot of DnD based worldbuilding elements that I enjoy, I like the magic system and stuff) but yeah it could literally have just been a fantasy setting with no isekai elements since it doesn't impact the story at all, they could have just had literally any other reason for the MC to be a baby in a necropolis or otherwise found by his adoptive parents