The Expanse series has Naomi Nagata, Avasarala, Bobbie Draper, and Drummer (among others)

The Revelation Space trilogy by Alastair Reynolds has the badass Ilia Volyova (cyborg space pirate; it makes sense in context lol) as a main character (not primary protagonist though) in the first two books and Ana Khouri (ex-military/assassin) is the primary protagonist in the second two (and major character in the first).

Some of Reynolds's other works also have strong female protagonists as well (e.g. Pushing Ice and the whole Revenger series). House of Suns is one of my favorites, and there are two protagonists, male and female, and have equal spotlight throughout.

Both of those are hard sci-fi, so hopefully that's your jam.