TLDR; Stick with the CG50 unless you find the new UI compelling
Released about six months ago, I finally picked up a Casio fx-CG100. Physically, it is a very pretty device, and the buttons feel great. I was excited to benchmark it and put it through my torture tests, but was pretty shocked by the results. It is actually a touch slower than the CG50 on all of my benchmarks, and uses the exact same algorithms as the CG50. That means that the gains in precision that we've seen with the fx-991CW do not carry over to the new flagship graphing calculator.
The UI has some welcome improvements, especially if you do a lot of linear algebra. On the main calculate page, defining vectors and matricies are only one button press away instead of digging through menus. I personally find the Catalog and Tools method of accessing functions to be a more intuitive method than the F-buttons, but your mileage may vary.
The biggest difference between the CG100 and the CG50 is that the CG100 lacks the ability to install additional programs. That means no khiCAS, and you're stuck with only what comes preinstalled. If I wasn't a collector/enthusiast, I'd strongly recommend giving this particular calculator a hard pass. As it is, exploring the unique UI and enjoying the physical attributes of the calculator make it worth it to me, and I'm happy to have it in my arsenal.