Many of these channels are super famous, so I'm probably not discovering those to anyone, but anyway. Here are some of my favorites, in alphabetical order:
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AsapSCIENCE (he/him both of them) - Science education. They also have a podcast called Sidenote that supplements their channel, in which they have longer conversations around the topics of their videos or other topics, and you get to enjoy their personalities.
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Carlos Maza (he/him) - Former Vox journalist, now turned independent. He makes amazing leftist video essays.
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Contrapoints (she/her) - Video essays, often around online conversation topics and debates.
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Faline San (any pronouns, but prefers he/him) - I just stumbled upon him a few days ago, and I have binged most videos on his channel. Hilarious storytelling of mostly mundane things. Great for lighthearted content.
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Freya Holmér (she/her) - Game developement, often complicated stuff that goes way over my head, but her "Math for Game Devs" videos are a must watch for any aspiring game developer. She breaks down really complicated stuff and makes it incredibly easy to understand and apply into your games. She also streams on twitch sometimes.
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JaidenAnimations (she/her) - Comedy animated videos, mostly around gaming or personal life storytelling. Also streams on twitch.
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JustWrite (he/him) - Video essays about movies, and sometimes other media.
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münecat (she/her) - More video-essays around leftist topics. Also makes music on twitch.
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Shonalika (they/them) - Can you guess it? Yes! More video-essays! (and some music).