I use it for Starfield at the moment and it works okay. There's definitely some caveats though and it's still something that might require some tinkering / fixing. That said, the last time I tried Skyrim on Linux it also ran atrociously bad, the framerate was just not what I'd expect from my system and way worse than what I had on Windows with my previous system (which was much worse in). Similar experience when I tried Fallout NV. The performance dipped down into the low two digits and I didn't even really went into modding all sorts of stuff into either of them.

Starfield runs much better but I suspect it might still perform better in Windows. Not sure what it is but it seems that gamebryo just does not run well under Linux, or rather even worse than under Windows.

Maybe I try NV again at some point since I kinda want to play it before season 2 of the TV show. It's been a while since I tried so maybe there had been some fixes & improvements since then and I've seen some engine optimization mod too.

I'd still hope for a native mod manager for Linux though. R2Modman is kinda decent but does not support Bethesda games.