~~The comic makes sense to me if the driver is not identifying as a trans man while the passenger is a lesbian. It doesn't make sense to me if they're nonbinary or any other form of gender queer. I say this as someone whose spouse has come out of nonbinary and have friends whose spouses have come out as nonbinary. It doesn't feel "divorce worthy" to me. To be honest, I don't view your partner coming out as trans as being "divorce worthy" but I would at least understand an amicable split. It feels enbyphobic to split because they're nonbinary.~~

~~That's why I interpret it at the driver being a man, because the comic makes more sense that way to me and it feels, to me, maybe a little bigoted otherwise. But I say that with a grain of salt because I'm not sure if the comic is meant to be like a joke or a story or even biographical of the author's own life. Not sure if that makes sense lol.~~

The comic is biographical of the author's life. Also the extra panel clearly addresses everything.

It says the driver is open to dating all genders. So only the wife doesn't lineup here.