If you knew and understood what actually goes on in this world, you would be "depressed" regardless of the chemicals in your brain working or not. All the happy pills in the world, and trust me from experience, all the best drugs in the world, would not get rid of genocide, fascism, or a world built upon capitalism, that at its very core is based upon exploitation, subjugation, and oppression of half of the world, and the mass destruction of most of the Earth's species and the planet itself to fuel the greed and sole benefit of the worlds greatest sociopaths, wherein you happen to be one of the few lucky ones who can live in a tiny bubble where you are completely unaware of the extent of mass suffering and death that is occurring in the neighborhoods you don't go to and the countries that are too far away for you to care about. If you read through the publicly available documents of what the CIA in the US did in the 20th century alone, you would not think coming to the conclusion that humans as a species are irredeemable could only be the result of a disfunctioning brain. I'm not even an antinatalist, I'm just autistic and study a lot of history.