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Yeah, well where do you draw the line though? When normies talk about something being GMO, it always involves fancy labs, modern biotechnology and greedy corporations.
When wolves were modified to become dogs, people were effectively practicing low-tech genetic manipulation, but people usually don't think of it in those terms. Well, what about when the same thing happens without humans in charge of the process? Like, why do peacocks have such impressive tail feathers? Humans weren't involved in that manipulation, so does it still count? It's the peacocks themselves who did all the selective breeding and genetic manipulation.
What about when one species causes another to change? Just think of the relationship between orchids and hummingbirds for example. What about wasp-mimic flies or harmless snakes that look a lot like venomous ones? Surely, that's a result of genetic manipulation too. This is getting completely ridiculous, so I guess we need to draw the line somewhere.
Yeah, I do think the lab kind should be in a different category, but it shouldn't be shunned. It's a new way to do an ancient thing. The biggest difference is that genes from one species (or designed ones) can't get into a different one naturally (very frequently or easily —viruses can, but that's pretty limited without humans managing it). Usually the genes need to be present in a population for them to be selected for. Either that, or caused by a random mutation, which decreases the rate this can happen.
It's potentially dangerous, if it isn't managed properly. It could introduce some issues that wouldn't be with slower methods. However, it's not a serious concern. It being modified in a lab doesn't inherently make it harmful any more than all the other ways does. It's just far more capable. It can solve some huge issues, and we shouldn't shun it.