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dude@lemmings.world

The Risk Too Many People Are Taking With Ozempic (slate.com)

submitted 2 days ago by dude@lemmings.world to c/news@lemmings.world

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[–] theunknownmuncher@lemmy.world 23 points 2 days ago* (last edited 2 days ago) (2 children)

Did you read the article? It is warning about over-prescribing to people who are not at risk of heart disease, stroke, and other obesity-related issues or who already naturally produce GLP-1 correctly.

If a patient’s body is already producing GLP-1 at normal or elevated levels, prescribing a long-acting agonist isn’t correcting a deficit; it may be amplifying a signal that’s already there. Are the potential effects of that a risk the prescriber and patient are willing to take on?

I am not arguing that these drugs are dangerous and should be restricted. I am arguing that the question of who should receive them has not been asked with nearly enough precision, and that a baseline GLP-1 measurement is an obvious, low-cost starting point.

Seems pretty reasonable?

[–] Alk@sh.itjust.works 1 points 2 days ago (1 children)

I think it's well understood that people who produce glp1 correctly can still be obese and need weight loss and these drugs help with that. That's the whole point of the drug. To provide more glp1 than is needed to lose weight easily.

[–] theunknownmuncher@lemmy.world 8 points 2 days ago* (last edited 2 days ago) (1 children)

these drugs help with that

or they cause gastrointestinal conditions in these people, resulting in weight loss (and malnutrition) that is a symptom of the new problem rather than the drug itself. If you don't have GLP-1 problems, then GLP-1 is not a solution, and dieting will be effective.

[–] Alk@sh.itjust.works 4 points 2 days ago (50 children)

The entire point of glp1 is to prescribe when dieting isn't effective.

[–] SaveTheTuaHawk@lemmy.ca 1 points 1 day ago (1 children)

You mean when people refuse to change their diets and restrict caloric intake.

[–] Alk@sh.itjust.works 1 points 1 day ago

Have you read any of the other comments here? People aren't just "refusing" to change their diets. I'm not going to type my response again but see my comment here. Or maybe this comment by someone else. Or maybe this one. The point is that when 20+% of the population are afflicted with something, it's not a problem of them "refusing" to fix it themselves. It's a systemic issue.

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[–] BanMe@lemmy.world 0 points 2 days ago (1 children)

GLP-1 has already been exploited for 50 years, you know it as the processed food revolution, aka why half of you reading this have problems with your own refined sugar consumption but feel powerless to change it. We need more research but this is a weapon in a war that started a while ago.

[–] theunknownmuncher@lemmy.world 0 points 2 days ago

That's interesting, I'll look into that more.