GenZedong

From the lens of anti-imperialism while secession might weaken the empire it will destabilize the whole continent and likely result in wars, genocides, and dictatorships.

This is a good point and my mind goes to a similar place. One area I was thinking about was nukes and whose hands they may fall into. The US has some real unhinged elements to it and the last thing the world needs is some far-right death cult faction getting their hands on one and deciding it's worth it to fire it off at god knows who because the US is falling apart.

As a point of contrast: as unhinged as Trump talks, his behavior still seems to fit fairly predictably within the realm of gangster empire lashing out in its decline, i.e. brutal and disorientingly mask off but not interested in destroying himself in the process. Some of the Christo-Fascist fanatical elements OTOH, the true believers in rapture style thinking, I'm not so sure about their survival instincts.

That said, nukes are probably more so me going to worst case scenario thinking. The more immediate concern, I think, would be a resurgence of violent, vigilante style racism and individual reactionary states doubling down on racist and otherwise repressive policies without the federal process to slow down their devolvement back toward civil war era confederacy thinking. Liberalism has shown time and time again how feckless it is in opposing the far right elements of the US, and liberal administrators wouldn't magically become more leftist all of a sudden if a bunch of states seceded. So it would probably result in a lot of people outright fleeing states believed to be more "conservative" or picking sides in a way that hastens on a kind of reenactment of the civil war but on more religious-like grounds of differing bougie interpretations of the constitution than anything else.

Though this is also assuming any kind of broad scale secession. A single state trying it without broader agreement in doing so may not go much of anywhere.