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YouTube adds new hurdles for ad blockers, and there's currently no way around it
(www.androidauthority.com)
This is a most excellent place for technology news and articles.
They did successfully disable uBlock Origin for me on chrome but I found a workaround that so far seems to be sticking fine despite further updates. Still see comments and descriptions fine on youtube. Occasionally things take a little longer to load than I would expect but I'll take a longer load time on a black screen over being stuck watching dogshit ads relentlessly.
uBlock also seems to just continue to work on FireFox which also plays youtube fine.
Ublock Lite still works on Chrome. There are no custom filters and it doesn't block a lot of annoyances (like "Sign In With [brand]"), but it gets the job done for most people.
But honestly if you want have the most reliable adblocking experience, then Firefox w/Ublock Origin is still your best bet (also YouTube ReVanced for mobile and SmartTube/SmartTubeNext for TVs).