this post was submitted on 28 Nov 2025
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Public Health

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There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests - Ars Technica (arstechnica.com)
submitted 4 months ago by otters_raft@lemmy.ca to c/publichealth@mander.xyz
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In trial, 82% saw weight rebound and cardiovascular health reverse after withdrawal.

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[โ€“] krooklochurm@lemmy.ca 1 points 4 months ago (2 children)

I mean.

There may be nuances I don't understand.

But I've never understood how so many people have bodies that disobey the laws of thermodynamics and the conservation of energy.

[โ€“] dmention7@midwest.social 6 points 4 months ago* (last edited 4 months ago)

There may be nuances I don't understand.

You probably could have stopped there, honestly.

The human body is complex enough that it would honestly be staggering if everyone's body digested, metabolized, stored excess caloric content, and used that stored energy in the exact same way.

[โ€“] SuperNovaStar@lemmy.blahaj.zone 5 points 4 months ago

From what I understand, the "set point" for the hormonal triggers that decide whether someone stores fat or burns it are out of whack.

So someone might be so calorie-deficient that it becomes a serious issue, and yet their body is still trying to store fat instead of burning it.

This makes losing weight a lot harder and it's a lot more miserable for them, as opposed to someone who can just eat a little less and their body will smoothly transition over to burning fat to make up the difference.