IMO, it's a difference in severity, not in kind. It's a fairly regular thing for bullying victims to kill themselves or get seriously injured or killed by their bullies. Go a couple of decades back and out homosexuals, especially men, were exactly where trans people are now. Remember how the Republicans handled AIDS, or how male homosexual acts were literally illegal in many western countries until like the 90s or early 00s?

Bottomline is, don't say your "friend" is a different sexuality or gender than you know they are, just as a test.