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The answer to the The Fermi Paradox could be that space is full of dead aliens
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Can you even form a civilization without being an pleasure seeking organism? Chemicals that produce pleasure or pain are fundamental to how life motivates individual creatures into doing basically anything.
If an alien body doesn't produce the good/bad chemicals then what motivates it to do anything?
How about a civilization that doesn't have chemistry at all? Set off a von Neumann machine to colonize the universe and biology is irrelevant after that.
You ignored the other "maybes" I threw out there, BTW. It only takes one of those to work in one situation and the Fermi Paradox is off to the races.