this post was submitted on 06 Nov 2025
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Pharmacology - Drug Nerds

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Semaglutide was associated with significantly reduced risk for first-time AD diagnosis, most strongly compared with insulin (hazard ratio [HR], 0.33 [95% CI: 0.21 to 0.51]) and most weakly compared with other GLP-1RAs (HR, 0.59 [95% CI: 0.37 to 0.95]). Similar results were seen across obesity status, gender, and age groups.

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[โ€“] ThorrJo@lemmy.sdf.org 3 points 4 months ago (1 children)

I haven't done a deep dive in a while, but last I checked there was some thinking that Alzheimers may be caused by inflammation possibly brought on by a leaky blood-brain barrier, and IIRC this was proposed as why eating a poor diet and/or having diabetes is such a risk factor.

I probably should research the topic again, I have a hereditary high risk of Alzheimers, although granted so did my dad and it didn't get him til his mid 80s.

Anyway..... odds on whether this replicates?

Odds of low-frequency horrible side effects to GLP-1 drugs being found?

From my reading it seems to be becoming more and more clear that inflammation is the real culprit behind the overwhelming majority of aging-related illnesses. But insurance will probably not pay for these drugs, because fuck you.