As of now, "no major adverse reactions have been reported."

Like all new practices and inventions, time will tell.

"Clinical trials have already demonstrated promising results. To date, Bone-02 has been used successfully in over 150 patients, with procedures showing reduced operative time, minimal blood loss, and faster recovery. In one notable case, a patient with a shattered wrist bone underwent treatment that restored full function within three months, avoiding the trauma of open surgery and follow-up removals. These trials, conducted at Sir Run Run Shaw Hospital, highlight the adhesive's safety profile -no major adverse reactions have been reported, and its biocompatibility addresses long-standing challenges in orthopedic adhesives dating back to the 1940s."

"Of course, challenges remain. Wider clinical trials are needed to validate its efficacy across diverse patient populations, including those with load-bearing fractures like femurs or spines. Regulatory approvals beyond China will require rigorous testing to ensure long-term safety. Questions about scalability-how to produce Bone-02 affordably and distribute it globally—also loom. Yet, the optimism is palpable; as Dr. Lin himself shared in interviews, this innovation stems from a desire to alleviate patient suffering based on real-world clinical needs."^[[1] https://dunapress.org/breaking-barriers-in-bone-repair-the-dawn-of-bone-02-adhesive/ | https://web.archive.org/web/20250928040842/https://dunapress.org/breaking-barriers-in-bone-repair-the-dawn-of-bone-02-adhesive/]