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iFixit wants to fix the soldering iron
(www.engadget.com)
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You'd want more than one cell. You'd be pulling 23amps from a 4.2v 18650 to give the same 100w at 20v power as you get from a top usbpd power supply.
There are 18650s that do 30 amps for short bursts, but it would get as hot as the iron and be empty in 5 min
I would not want multiple cells for reasons of ergonomics and convenience.
I probably don't need 100W for most field soldering. 60 is plenty, and temperature-controlled soldering irons usually don't need to pull high current continuously. It would need 60W for maybe 10 seconds when powered on, and when heating something large. The rest of the time, it takes relatively little power to keep the tip hot.
What I'm describing is, of course not the right tool for production soldering. It's for field work.
I've got a Ts80p which is a qc3 usbc soldering iron for that. It's crazy powerful for it's size and runs off a pretty small anker powerbank. You could slide that into your sleeve to go portable and one handed
That's similar to the iFixit iron, as is the less expensive Pinecil.
Those are probably the best options currently available, but I want something more compact and self-contained.