this post was submitted on 06 Jan 2026
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covid

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In August an immunologist declared the "Leonardi Effect" had received a "decent burial"

Fast forward to today: a new preprint shows what I warned about in 2020

Persistent SARS-CoV-2-induced impairment of CD8 T cell responses to community-acquired pathogens

I was right Key finding: Post-COVID patients show markedly reduced T cell reactivity to common pathogens (influenza, Staph, VCZ) which is evidence of lasting immune dysregulation favoring secondary infections and viral reactivation

Link

This is the scenario I described years ago: accelerated CD8 aging/paralysis/exhaustion/senescence, poorer control of pathogens.

We ignored it at our peril. Rising "mystery" infections, cancers, herpes flares? Not a coincidence

after covid, patients show profound mitochondrial defects in T cells specific for common pathogens

Classic signs of T cell exhaustion/senescence

This is the scar I predicted in 2020

Aged, dysfunctional T cells that can’t properly control chronic viruses

Science eventually catches up.

Protect your T cells: vaccinate, mask in crowds, avoid reinfection

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[–] JoeByeThen@hexbear.net 36 points 4 months ago (10 children)

Do NOT look at the replies. jesus-christ

Anyway yeah. We're pretty, pretty fucked. this-is-fine I'm glad to see there's some folks starting to mask again due to how hard this flu variant is hitting, but I'm not hopefully for all those brainworms folks in the replies. If h5n1 kicks off in the next few years, the death count is gonna be through the stratosphere. Gonna be like The Stand.

[–] dat_math@hexbear.net 14 points 4 months ago (8 children)

The Stand.

the station 11 at home (in terms of QOL, not literature):

[–] JoeByeThen@hexbear.net 11 points 4 months ago (5 children)

I'm not familiar with Station 11, worth checking out?

[–] doubledealer@hexbear.net 14 points 4 months ago (1 children)

The TV adaptation is great. I wish I could watch it without knowing anything about it again.

[–] JoeByeThen@hexbear.net 11 points 4 months ago* (last edited 4 months ago) (1 children)

Heard, I'll add it to my list. Is it over/complete?

[–] doubledealer@hexbear.net 12 points 4 months ago

It was billed as a miniseries so technically yes. There was some chatter about adapting the second book but that seems unlikely so also yes.

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