A new study finds that getting your blood pressure taken while you’re lying down may give a more accurate reading that could show signs of heart disease risks. Even though the new study found something different, researchers agree that sitting up is still the best way to take blood pressure. Experts say that people should make it a priority to know their blood pressure numbers and act on them, because high blood pressure can make someone more likely to have dangerous heart events. New study shows that getting your blood pressure checked while you’re lying down may give more exact results.

Every time you go to the doctor, your blood pressure is taken for a reason. Blood pressure is often a good indicator of serious health problems, like the chance of stroke, heart disease, and even dying too soon.

So, it’s important to get the most exact reading of your blood pressure so you can take care of your health.

The American Heart Association (AHA) gave a talk earlier this month about how a person’s physical position when their blood pressure is taken can affect their blood pressure number, which in turn can affect how well they can predict certain health risks.

All of it comes down to where an adult is when they get a high blood pressure number.

Adults who had high blood pressure both when they were sitting up and when they were lying flat on their backs were more likely to have a stroke, heart failure, die too soon, or have heart disease than those who didn’t have high blood pressure in either pose.

CRAB is the name of a type of bacteria that can cause dangerous infections in the blood, lungs, and urinary tract, according to the U.S. Centres for Disease Control and Prevention. A group of strong medicines called carbapenems can’t kill it, which is a bad thing.

Researchers from Harvard University and the drug company Hoffmann-La Roche found that zosurabalpin, a new type of antibiotic, can kill A. baumannii in a study that came out on January 3 in the journal Nature.

Dr. Kenneth Bradley, global head of infectious disease discovery at Roche Pharma Research and Early Development and researcher, told CNN that Zosurabalpin works in a way that isn’t like anything else on the market.

His explanation was that this was a new way to do things, both in terms of the compound itself and the way it kills germs. It is hard to fight A. baumannii because it is a Gram-negative bacteria, which means it has protective membranes on both the inside and the outside.

Scientists first tried to find a molecule that could get through those double membranes and kill the germs. Then, they worked on making it even better.

Researchers picked one changed molecule after working for years to make many compounds stronger and safer.

How does it do its job? Zosurabalpin stops lipopolysaccharides, which are big molecules, from moving to the outer membrane of bacteria. There, they keep the protected membrane intact. This makes the molecules build up inside the bacteria cell until the cell becomes so poisonous that it dies.

More than 100 CRAB samples were used in the study, and zosurabalpin worked on all of them. It also lowered the amount of bacteria in mice that had asthma caused by CRABs and kept mice from dying of sepsis caused by the bacteria.

Researchers told CNN that Zosurabalpin is now being tried in phase 1 clinical trials to see if it is safe for people to use.

cross-posted from: https://midwest.social/post/6252553

Dec 7 (Reuters) - The Biden Administration on Thursday announced it is setting new policy that will allow it to seize patents for medicines developed with government funding if it believes their prices are too high.

The policy creates a roadmap for the government's so-called march-in rights, which have never been used before. They would allow the government to grant additional licenses to third parties for products developed using federal funds if the original patent holder does not make them available to the public on reasonable terms.

White House advisers said on a press call that cost to consumers is a factor government agencies may consider when thinking of using march-in rights.

"We'll make it clear that when drug companies won't sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less," White House adviser Lael Brainard said on the call.

. . .

“We’ve found that antioxidants activate a mechanism that causes cancer tumors to form new blood vessels, which is surprising since it was previously thought that antioxidants have a protective effect,” said Martin Bergö, a new study’s author. “The new blood vessels nourish the tumors and can help them grow and spread.” It's worth noting that there's no harm in consuming normal antioxidant-rich foods in normal quantities, though.

Over the past several years, increasingly destructive hurricanes, wildfires, blizzards, and other extreme weather events have made it clear that the effects of climate change aren’t some future hypothetical, but our current reality. Not to be outdone, the summer of 2023 has been coming in hot — literally — with July shattering the record for the planet’s hottest month, and coming to a close with “numerous fires” breaking out in the Arctic circle. And while the recent high temperatures and debilitating humidity may not be responsible for as much property damage as a hurricane, it’s been disastrous for our mental health.

Diabetes cases are likely to skyrocket over the next few decades, new research out this week has found. The study estimates that more than a billion people worldwide will be living with the chronic condition by 2050—roughly double the amount of cases seen today. The prevalence of diabetes is expected to be especially high in parts of Africa and the Middle East, but dozens of countries could experience substantial increases.

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In the simplest terms, diabetes is defined as having chronically high levels of blood sugar. This usually happens due to a breakdown in our production of or response to insulin, a hormone that helps move sugar from the bloodstream to our cells. People with type 1 diabetes, for instance, have an overzealous immune system that attacks the cells responsible for making insulin. And those with type 2 diabetes develop a resistance to insulin’s effects and can eventually stop producing it altogether.

Thanks to medications and better blood sugar monitoring, diabetes is no longer the death sentence it once was. But it can still lead to serious complications like nerve damage and chronic kidney disease, especially if not managed probably. It also often raises the odds of many other health conditions, including heart attacks, stroke, and dementia. And according to the authors of a study published Thursday in the Lancet, the burden of diabetes will only go up from here.

The research comes from scientists at the Institute for Health Metrics and Evaluation (IHME), based at the University of Washington’s School of Medicine. To come up with their predictions, the team used the latest data from the Global Burden of Diseases study, a long-running research project also managed by the IHME that tries to track the prevalence of and harm caused by many health conditions and illnesses.

Based on the GBD data, there were about 529 million people living with diabetes worldwide in 2021. After adjusting for age, the current global prevalence was around 6.1%. But by 2050, 1.31 billion people will have some form of diabetes, the authors found. The highest age-standardized prevalence rate for a large region is projected to be in North Africa and the Middle East, at 16.8%, but nearly half of the world’s over 200 countries and territories will have rates higher than 10%.

“The rapid rate at which diabetes is growing is not only alarming but also challenging for every health system in the world, especially given how the disease also increases the risk for ischemic heart disease and stroke,” said lead author Liane Ong, a lead research scientist at the IHME, in a statement released by the organization.

Over 95% of these cases are expected to be type 2 diabetes. And the single most significant risk factor associated with type 2 was high body mass index. But the authors note that many other important factors, including low levels of exercise, poor diet, and a person’s genetics, can influence the risk of developing diabetes and the potential harm or death it can cause. So preventing or managing diabetes cases now and in the future will require widespread improvements in our environment and availability of health care, the authors say.

“Some people might be quick to focus on one or a few risk factors, but that approach doesn’t take into account the conditions in which people are born and live that create disparities worldwide,” said study author Lauryn Stafford, a research fellow at IHME. “Those inequities ultimately impact people’s access to screening and treatment and the availability of health services. That’s precisely why we need a more complete picture of how diabetes has been impacting populations at a granular level.”

What a surprise. /j

Well, guess I'm screwed since I bump my head, semicommonly…

Also, this is NPR, so it's unsurprising they whitewashed the U.S military.

Through its savvy but legal exploitation of the U.S. patent system, Humira’s manufacturer, AbbVie, blocked competitors from entering the market. For the next six years, the drug’s price kept rising. Today, Humira is the most lucrative franchise in pharmaceutical history. AbbVie orchestrated the delay by building a formidable wall of intellectual property protection and suing would-be competitors before settling with them to delay their product launches until this year. Over the past 20 years, AbbVie and its former parent company increased Humira’s price about 30 times, most recently by 8 percent this month. Since the end of 2016, the drug’s list price has gone up 60 percent to over $80,000 a year, according to SSR Health, a research firm. AbbVie did not invent these patent-prolonging strategies; companies like Bristol Myers Squibb and AstraZeneca have deployed similar tactics to maximize profits on drugs for the treatment of cancer, anxiety and heartburn. But AbbVie’s success with Humira stands out even in an industry adept at manipulating the U.S. intellectual-property regime.

“Humira is the poster child for many of the biggest concerns with the pharmaceutical industry,” said Rachel Sachs, a drug pricing expert at Washington University in St. Louis. “AbbVie and Humira showed other companies what it was possible to do.”

Lawyers for the unnamed girl said her parents took her to Frimley Park Hospital in Surrey, southeast England, with a high fever, drowsiness, and vomiting, Metro reported. These symptoms are "red flags for meningitis and sepsis," according to the BBC News, but doctors sent her home with paracetamol, or acetaminophen.

Her parents returned to the hospital when her condition worsened, and doctors diagnosed her with meningococcal sepsis. She later experienced multi-organ failure.

The severity of her sepsis later led to her needing the quadruple-limb amputations, Elizabeth-Anne Gumbel KC, who is representing the family, said, the BBC reported. The girl had above-knee amputations of both legs, and above-elbow amputations of her arms.

Her family argued that if doctors had immediately treated her with antibiotics, she would not have been so ill and might have kept her limbs.

More than 105,000 people are on the U.S. waiting list for an organ transplant. Thousands will die before it’s their turn. Thousands more never even get put on the list, considered too much of a long shot.

“The number of organs we have available are never going to be able to meet the demand,” said Dr. Amit Tevar, a transplant surgeon at the University of Pittsburgh Medical Center. “This is our frustration.”

That’s why scientists are looking to animals as another source of organs. A Maryland man lived two months after receiving the world’s first heart transplant from a pig last January — an animal genetically modified so its organs didn’t trigger an immediate attack from the human immune system. The FDA is considering whether to allow additional xenotransplantation experiments using kidneys or hearts from gene-edited pigs.

If the Food and Drug Administration agrees, the initial experiment will be outside a patient’s body. Researchers would place a pig-turned-humanlike liver next to a hospital bed to temporarily filter the blood of someone whose own liver suddenly failed. And if that novel “liver assist” works, it would be a critical step toward eventually attempting a bioengineered organ transplant — probably a kidney.

More complex is getting human cells to take over.

“We can’t take billions of cells and push them into the organ at once,” Ross said. When slowly infused, “the cells crawl around and when they see the right environment, they stick.”

cross-posted from: https://lemmy.ml/post/617067

U.S already has COVID, imagine the shit show that will happen when Monkeypox continues to spread like crazy. Yet here we are and the U.S still doesn't seem to give a shit.

Sending love to the immunocompromised; they do not deserve this.

It's one study, so more repetitive studies are needed, but I'm unsurprised.

What a surprise: consuming drugs that damage the body increases mortality.

Don't need to make the conditions for needed health if you can just scam people into getting them amirite capitalists? /s

Sources.^[Kalkman, H. O., & Feuerbach, D. (2016). Antidepressant therapies inhibit inflammation and microglial M1-polarization. Pharmacology & Therapeutics, 163, 82–93. doi:10.1016/j.pharmthera.2016.]^[Ohgidani, M., Kato, T. A., Mizoguchi, Y., Horikawa, H., Monji, A., & Kanba, S. (2016). Antidepressants Modulate Microglia Beyond the Neurotransmitters Doctrine of Mood Disorders. Melatonin, Neuroprotective Agents and Antidepressant Therapy, 611–620. doi:10.1007/978-81-322-2803-5_36]

This is just pathetic. Those studies are trying to imply that suppression of microliga activity can "improve" depression. They would totally view forcing in unneccessary emotional chemicals to make someone happier as "cUrInG dEpReSsIoN."

I do not want to imagine an immunocompromised person taking these drugs...

The drug industry is not going to like this lmao.

and people wonder why I'm freaked out about my health…